TR and LXR regulate ChREBP in a tissue selective manner
نویسندگان
چکیده
1 Gauthier et al. THYROID HORMONE RECEPTOR (TR) AND LIVER X RECEPTOR (LXR) REGULATE CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN (ChREBP) EXPRESSION IN A TISSUE SELECTIVE MANNER. Karine Gauthier * 1 , Cyrielle Billon C * 1 , Marie Bissler 1 , Michel Beylot 2 , Jean-Marc Lobaccaro 3 , Jean-Marc Vanacker 1 and Jacques Samarut 1 . 1 Institut de Génomique Fonctionnelle de Lyon; Université de Lyon; Université Lyon 1; CNRS; INRA; Ecole Normale Supérieure de Lyon; 46 allée d’Italie, 69364 Lyon France 2 Inserm ERI 22/EA4173, Faculté Rockefeller, Université Lyon1, Lyon, France 3 Unité Mixte de Recherche, Centre National de la Recherche Scientifique 6247, Clermont Université, Centre de Recherche en Nutrition Humaine d'Auvergne, 63177 Aubière Cedex, France *authors have equally contributed to the work Running Title: TR and LXR regulate ChREBP in a tissue selective manner Address correspondence to Karine Gauthier, IGFL, UMR5242, ENS de Lyon, 46 allée d’Italie, 69364 Lyon cedex 07, France. Phone: 33(0)472728616. Fax: 33(0)472728080. E-mail: [email protected]
منابع مشابه
Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.
Thyroid hormone (TR) and liver X (LXR) receptors are transcription factors involved in lipogenesis. Both receptors recognize the same consensus DNA-response element in vitro. It was previously shown that their signaling pathways interact in the control of cholesterol elimination in the liver. In the present study, carbohydrate-response element-binding protein (ChREBP), a major transcription fac...
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